Medication Indication Severe Adverse Effect Accutane cystic acne depression, headaches, psychosis, seizures, suicide Adderall attention deficit, hyperactivity depression, seizures Ambien  (zolpidem) insomnia amnesia, anxiety, cognitive impairment, depression, drowsiness, sleepwalking, sleep driving, worsening of depression, suicidal thoughts. Chantix smoking cessation suicidal thoughts estrogen hormone deficiency, regulation of menstruation depression Duragesic (fentanyl) pain control Somnolence, insomnia, confusion, asthenia, dizziness, nervousness, hallucinations, anxiety, depression, euphoria, tremor, abnormal coordination, speech disorder, abnormal thinking, abnormal gait, abnormal dreams, agitation, paresthesia, amnesia, syncope, paranoid reaction Interferons viral hepatitis agitation, depression, headache, suicidal thought, drug-seeking behavior Lariam malaria depression, psychosis Lamictal bipolar disorder, seizure disorder depression Lupron GnRH children with central precocious puberty, advanced prostate cancer Memory disorder, Mood swings, Nervousness Meridia (sibutramine) obesity depression Reglan gastric dysmotility depression, suicidal thought SSRI: Prozac, Paxil, Zoloft depression aggitation, irritability, seizures, psychosis, suicide Reserpine hypertension Anorexia, Dizziness, Nausea, Vomiting, Concentration Difficulty, Nervousness, Nightmares Xanax anxiety disorders Agitation, mental confusion, depression, headache, irritability, nervousness, slurred speech, sleep disturbances, euphoria, lethargy, stupor.